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13 февр. 2018 г. - The expression of major histocompatibility complex class II (MHC-II) molecules on tumor cells can predict response to immune checkpoint ...

Model for the Peptide-Free Conformation of Class II MHC Proteins

11 июн. 2008 г. - This work presents a molecular model for peptide-free class II MHC proteins that can help to interpret the conformational changes known to ...

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We introduce a new model for predicting binding affinities of peptides to class II MHC called the Regularized Thermodynamic Average, or RTA, model.

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Structural studies supported a view of MHC-I/peptide binding in which the side ... MHC-I structures of HLA-B35 allotypes complexed with 13-mer and 11-mer ...

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Deficiencies of MHC complex class I or II are rare primary immunodeficiencies, both of which are inherited in an autosomal recessive pattern. MHC class II ...

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20 июн. 2018 г. - Major histocompatibility complex class two {(MHC-II)} molecules are trans-membrane proteins and key components of the cellular immune ...

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LC−MS/MS analysis was used to identify endogenous MHC II peptides from splenic dendritic cells (DCs). Cell numbers were enriched in vivo with Flt3L-B16 ...

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Antigen presentation is mediated by MHC class I molecules, and the class II molecules found on the surface of antigen-presenting cells (APCs) and certain other ...

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However, while this canine enteropathy is heritable, there is no association with the canine MHC class II [6]. Mouse Models of Celiac Disease Nontransgenic ...

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Among the DcR3-modulated genes expressed by TAMs, those that encode proteins involved in MHC class II (MHC-II)–dependent antigen presentation were ...

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Therefore, one has to conclude that MHC II is necessary, but insufficient by itself to develop gluten-dependent enteropathy. This chapter will therefore highlight ...

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